Can’t get Motilium (domperidone) or want a different approach? Below are seven sensible alternatives—some are prescription medicines, others are natural or lifestyle changes. Each short note tells you what it helps with and what to watch for, so you can talk to your doctor with clear questions.
1. Metoclopramide (Reglan)
Metoclopramide works like domperidone to speed stomach emptying and ease nausea. It’s widely used but can cause drowsiness and, rarely, movement side effects if taken long-term. Good choice for short-term needs under medical supervision.
2. Low-dose erythromycin
Erythromycin is an antibiotic that, at low doses, can act as a prokinetic and help with slow gastric emptying. It’s often used short-term because tolerance can build and antibiotic side effects are possible. Ask your clinician about timing and dosing.
3. Prucalopride
Primarily prescribed for chronic constipation, prucalopride can help bowel motility and improve some digestive symptoms. It’s a prescription option worth discussing if constipation or slow transit is part of the problem.
4. Ginger
Ginger is one of the best-studied natural options for nausea. You can take it as tea, candied slices, capsules, or a small fresh piece. It’s generally safe but check with your doctor if you’re on blood thinners or pregnant.
5. Chamomile and other gentle herbs
Chamomile tea can soothe mild digestive discomfort and help with bloating or anxiety-related upset. It’s mild and often well tolerated. Avoid if you have ragweed allergies or take sedatives without checking first.
6. Probiotics
Targeted probiotics can improve gut balance and reduce bloating or irregular digestion for some people. Strains like Lactobacillus and Bifidobacterium are commonly used. Results vary, so try one product for a few weeks and note any changes.
7. Practical diet and habit changes
Small, consistent changes often help as much as medicines: smaller meals, slower eating, low-fat choices, and avoiding late-night heavy meals. Also try timing medications for nausea before meals and keeping hydrated. These steps reduce symptoms without side effects.
Want a quick next step? Pick one option that fits your situation—natural first if symptoms are mild, prescription if symptoms are moderate or persistent—and check with your healthcare provider. If you have heart problems, take other meds, or are pregnant, bring those details to the appointment so your clinician can recommend the safest alternative.
If you want the full breakdown with doses, side-effect details, and a checklist to discuss with your doctor, read the complete article from February 2025 that compares all seven options and helps you choose what fits your health needs best.
