One dose of disulfiram can make someone who drinks alcohol feel very sick — that’s the point. If you or someone you care about is trying to stop drinking, disulfiram (brand name Antabuse) is a drug doctors sometimes use to discourage drinking by causing a strong, unpleasant reaction when alcohol is consumed.
Disulfiram blocks an enzyme that helps the body break down alcohol. When alcohol builds up, you may get flushing, nausea, headache, fast heartbeat, and low blood pressure. Those effects can start within 10 to 30 minutes after drinking and last for hours.
Typical dosing starts at 250 mg once daily. Some doctors give 500 mg on the first day, then reduce to 250 mg daily. Others keep patients on 250 mg right away. The exact dose depends on your doctor’s plan, medical history, and how well you tolerate the medication. Never change dose without talking to your prescriber.
Disulfiram is meant to be part of a broader recovery plan: counseling, support groups, and medical follow-up work together to improve success.
Common side effects include drowsiness, tiredness, headache, and a metallic or garlic taste. More serious risks involve liver damage and severe reactions if you drink alcohol. Your doctor will check liver enzymes before starting disulfiram and again during treatment.
Disulfiram interacts with many things besides alcoholic drinks. Cough syrups, mouthwashes, some vinegars, sauces, and even skin products or medications that contain alcohol can trigger a reaction. Always read labels and tell healthcare providers you’re taking disulfiram.
Don’t take disulfiram if you have severe heart disease, severe liver disease, or if you’re pregnant. Talk to your doctor if you’re breastfeeding. If you miss a dose, take it as soon as you remember unless it’s almost time for the next dose. Avoid double-dosing.
If you plan to drink alcohol again, you need to stop disulfiram first. The drug can stay active for up to two weeks, so your doctor will advise how long to wait before drinking safely.
Monitoring is important. Expect regular check-ins, liver tests, and honest conversations about cravings and side effects. If you feel very tired, develop yellow skin or eyes, severe stomach pain, or mood changes, contact your doctor right away.
Disulfiram can help people who want a strong external deterrent against drinking, but it’s not a cure. It works best with counseling and support. If you’re thinking about disulfiram, ask a healthcare provider about whether it fits your goals and health profile. They’ll help you weigh the benefits and risks and set up safe follow-up care.
