Looking for alternatives to Motilium (domperidone)? Maybe it’s restricted where you live or you’re worried about side effects. Good news: there are several other ways to treat nausea or slow stomach emptying. Below I list common drug options, what they do, and simple non-drug steps you can try right away.
Metoclopramide is the most common substitute. It helps move food through the stomach and can reduce nausea. Watch for movement-related side effects (like tremors or restlessness) if you take it long term, and use the lowest effective dose for the shortest time your doctor recommends.
Low-dose erythromycin can act as a prokinetic by stimulating stomach contractions. It works quickly but is usually a short-term option because it’s an antibiotic and can interact with other drugs. Also ask about heart rhythm risks if you have cardiac issues.
Mosapride and itopride are used in many countries as prokinetics with generally milder central side effects than metoclopramide. Availability depends on where you live, so check with a local prescriber or pharmacist.
Ondansetron and other antiemetics (like meclizine or promethazine) don’t speed up gastric emptying, but they can control nausea. These are useful when vomiting or severe nausea is the main problem rather than slow motility.
Note about safety: several medicines that affect gut movement can also affect heart rhythm (QT prolongation) or interact with enzymes like CYP3A4. Tell your clinician about all meds, supplements, and underlying heart issues before starting anything new.
Small, frequent meals help a lot. Large or fatty meals slow digestion and can worsen nausea. Try six small meals instead of three large ones and avoid rich, greasy foods.
Ginger is a simple, well-studied option for nausea. Fresh ginger, ginger tea, or low-dose supplements can reduce symptoms for many people without major side effects.
Chewing gum after meals, sitting upright for 30–60 minutes after eating, and gentle walking can help move food through your stomach. If constipation is making symptoms worse, treating it often improves overall digestion—ask about a safe laxative or fiber plan.
Sea-Bands (acupressure wristbands) and relaxation techniques can reduce motion- or anxiety-related nausea for some people. These aren’t medical fixes for severe gastroparesis but they’re worth trying alongside other steps.
Which one is right? That depends on your symptoms, other health problems, and drug interactions. If domperidone was stopped for heart-safety reasons, your doctor will want to pick an option with a safer cardiac profile. Ask about short-term trials, monitoring, and what side effects to watch for.
Have questions about a specific drug or herb and how it fits with your health history? Talk to your healthcare provider or pharmacist. They can match an option to your needs and keep you safe.
